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To benchmark our findings against randomized evidence, we first applied eligibility criteria after SUSTAIN-6 that required patients to be at moderate or high cardiovascular risk 11
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Prevention: the 6-site rotation system above, combined with proper injection technique (don't inject through the same skin puncture hole twice, don't massage the injection site aggressively post-injection), reduces lipohypertrophy incidence to under 5% (Blanco et al., Diabetes Therapy , 2013)